Insulin-like growth factors decrease oxygen-regulated erythropoietin production by human hepatoma cells (Hep G2)

URN to cite this document:: urn:nbn:de:bvb:355-epub-269468
DOI to cite this document:: 10.5283/epub.26946

Scholz, H. ; Baier, W. ; Ratcliffe, P. ; Eckardt, K. ; Zapf, J. ; Kurtz, Armin ; Bauer, C.

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Date of publication of this fulltext: 04 Dec 2012 13:52

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Abstract

We examined the effects of insulin-like growth factors (IGFs) and insulin on erythropoietin (EPO) production by human hepatoma cells (Hep G2). Compared with normoxia (20% O2), EPO production by Hep G2 cells during a 72-h incubation was stimulated fivefold by exposure to low oxygen tension (1% O2) and nearly threefold by exposure to cobalt chloride (100 microM). IGF-I caused a ...