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Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2)

Kurtz, Armin, Eckardt, K. U., Pugh, C., Corvol, P., Fabbro, D. and Ratcliffe, P. (1992) Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2). The American journal of physiology. Cell physiology 262 (5 Pt 1), C1204-C1 210.

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Abstract

Using the human hepatoma cell line Hep G2, we have studied a possible role of protein kinase C (PKC) activity for regulation of erythropoietin (EPO) production. During a 72-h incubation, EPO production by the cells was stimulated sevenfold by exposure to low oxygen tension (1%) and threefold by exposure to cobaltous chloride (100 microM). The phorbol ester phorbol 12-myristate-13 acetate (PMA) ...

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Item type:Article
Date:1992
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
1317101PubMed ID
Classification:
NotationType
1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineMESH
Alkaloids/pharmacologyMESH
Carcinoma, Hepatocellular/ultrastructureMESH
Erythropoietin/geneticsMESH
HumansMESH
Isoquinolines/pharmacologyMESH
Liver Neoplasms/ultrastructureMESH
Oxygen/pharmacologyMESH
Piperazines/pharmacologyMESH
Protein Kinase C/metabolismMESH
RNA, Messenger/metabolismMESH
StaurosporineMESH
Tetradecanoylphorbol Acetate/pharmacologyMESH
Tissue DistributionMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:26948
Owner only: item control page

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