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Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2)

URN to cite this document:
urn:nbn:de:bvb:355-epub-269483
Kurtz, Armin ; Eckardt, K. U. ; Pugh, C. ; Corvol, P. ; Fabbro, D. ; Ratcliffe, P.
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Date of publication of this fulltext: 04 Dec 2012 13:53


Abstract

Using the human hepatoma cell line Hep G2, we have studied a possible role of protein kinase C (PKC) activity for regulation of erythropoietin (EPO) production. During a 72-h incubation, EPO production by the cells was stimulated sevenfold by exposure to low oxygen tension (1%) and threefold by exposure to cobaltous chloride (100 microM). The phorbol ester phorbol 12-myristate-13 acetate (PMA) ...

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