Calmodulin antagonists stimulate renin secretion and inhibit renin synthesis in vitro

URN to cite this document:: urn:nbn:de:bvb:355-epub-269499
DOI to cite this document:: 10.5283/epub.26949

Della Bruna, R. ; Pinet, F. ; Corvol, P. ; Kurtz, Armin

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Date of publication of this fulltext: 04 Dec 2012 13:55

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Abstract

To find out whether calmodulin activity could be a common denominator for the cellular control of renin secretion and synthesis, we have examined the effects of calmodulin antagonists on the secretion and the synthesis of renin in primary cultures of mouse juxtaglomerular (JG) cells. We found that the calmodulin antagonists calmidazolium (CMDZ), N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide ...