Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-269553
DOI to cite this document:: 10.5283/epub.26955

Kurtz, Armin ; Kaissling, Brigitte ; Busse, Rudi ; Baier, Wolfgang

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Date of publication of this fulltext: 11 Dec 2012 13:00

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Abstract

Utilizing cocultures of mouse renal juxtaglomerular cells with bovine microvascular endothelial cells, we have examined whether endothelial cells exert direct influence on renin secretion from renal juxtaglomerular cells. In the presence of endothelial cells both spontaneous and forskolin (10 microM) or isoproterenol (10 microM) stimulated renin release were markedly attenuated. The stimulatory ...