Distinct hemodynamic and gastric effects of human CGRP I and II in man

URN to cite this document:: urn:nbn:de:bvb:355-epub-269565
DOI to cite this document:: 10.5283/epub.26956

Beglinger, C. ; Born, W. ; Münch, R. ; Kurtz, Armin ; Gutzwiller, J. P. ; Jäger, K. ; Fischer, J. A.

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Date of publication of this fulltext: 11 Dec 2012 12:57

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Abstract

The human calcitonin gene-related peptides I and II (or alpha and beta) (CGRP I and II) are encoded by two different genes, but they have 34 of the 37 amino acid residues in common. Human CGRP I more potently stimulated blood flow through the skin and carotid artery (p less than 0.01), and the heart rate (p less than 0.05), and plasma renin activity and aldosterone secretion than human CGRP II (p ...