Structure-function correlations in erythropoietin formation and oxygen sensing in the kidney

URN to cite this document:: urn:nbn:de:bvb:355-epub-269577
DOI to cite this document:: 10.5283/epub.26957

Le Hir, M. ; Eckardt, Kai-Uwe ; Kaissling, B. ; Koury, S. T. ; Kurtz, Armin

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Date of publication of this fulltext: 13 Dec 2012 08:52

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Abstract

The kidney is the main site of erythropoietin (EPO) formation. Oxygen sensing in the kidney itself plays a major role in the control of EPO synthesis. By in situ hybridization it has been established that the EPO-producing cells are situated in the interstitium of the cortical labyrinth, but they have not been precisely identified. Morphological findings provide new insights into the location and ...