Role of protein kinase C in renal vasoconstriction caused by angiotensin II

URN to cite this document:: urn:nbn:de:bvb:355-epub-269699

Scholz, H. ; Kurtz, Armin

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Date of publication of this fulltext: 04 Dec 2012 14:41

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Abstract

In this study we have examined the subcellar pathways along which angiotensin II (ANG II) causes renal vasoconstriction. Using the isolated perfused rat kidney model, we found that renal vasoconstriction produced by ANG II (100 pM) was not altered by the calmodulin antagonists calmidazolium (1 microM) and N-(6-aminohexyl)-5-chloro-1-naphthalensulfonamide (W-7, 10 microM) but was blunted by ...