Decline of erythropoietin formation at continuous hypoxia is not due to feedback inhibition

URN to cite this document:: urn:nbn:de:bvb:355-epub-269704

Eckardt, K. U. ; Dittmer, J. ; Neumann, R. ; Bauer, C. ; Kurtz, Armin

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Date of publication of this fulltext: 04 Dec 2012 14:42

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Abstract

Serum erythropoietin (EPO) levels in response to hypoxia are known to decline before an increase in blood oxygen carrying capacity. To define the possible mechanisms underlying this phenomenon, we have investigated 1) how renal EPO mRNA content and EPO production rate underlying the early kinetics of serum EPO levels change under different degrees of normobaric hypoxia, and 2) if a feedback ...