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Triggering of erythropoietin production by hypoxia is inhibited by respiratory and metabolic acidosis

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Eckardt, K. U. ; Kurtz, Armin ; Bauer, C.
Date of publication of this fulltext: 05 Dec 2012 10:35


Erythropoietin (EPO) production in response to hypoxic hypoxia is known to be attenuated by simultaneous hypercapnia. This study aimed to investigate whether this inhibitory effect of hypercapnia is 1) a direct effect of carbon dioxide or mediated by changes in pH or bicarbonate, 2) affects also carbon monoxide hypoxia, and 3) influences either the synthesis and release of EPO or the mechanisms ...


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