Triggering of erythropoietin production by hypoxia is inhibited by respiratory and metabolic acidosis

URN to cite this document:: urn:nbn:de:bvb:355-epub-269747
DOI to cite this document:: 10.5283/epub.26974

Eckardt, K. U. ; Kurtz, Armin ; Bauer, C.

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Date of publication of this fulltext: 05 Dec 2012 10:35

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Abstract

Erythropoietin (EPO) production in response to hypoxic hypoxia is known to be attenuated by simultaneous hypercapnia. This study aimed to investigate whether this inhibitory effect of hypercapnia is 1) a direct effect of carbon dioxide or mediated by changes in pH or bicarbonate, 2) affects also carbon monoxide hypoxia, and 3) influences either the synthesis and release of EPO or the mechanisms ...