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Renal mesangium is a target for calcitonin gene-related peptide

Kurtz, Armin, Schurek, H. J., Jelkmann, W., Muff, R., Lipp, H. P., Heckmann, U., Eckardt, Kai-Uwe, Scholz, Holger, Fischer, J. A. and Bauer, Christian (1989) Renal mesangium is a target for calcitonin gene-related peptide. Kidney international 36 (2), pp. 222-227.

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Abstract

Rat calcitonin gene-related peptide (CGRP alpha; EC50, 1 nM) was shown to stimulate cAMP formation in cultured rat renal mesangial cells. CGRP concentration dependently (EC50, 1 nM) also inhibited contraction of mesangial cells by angiotensin II (10 nM). Angiotensin II (10 nM) caused a transient increase of the intracellular calcium concentration from 140 nM to 480 nM in the mesangial cells, but ...

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Item type:Article
Date:1989
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
2550694PubMed ID
Classification:
NotationType
Angiotensin II/pharmacologyMESH
AnimalsMESH
Calcitonin/pharmacologyMESH
Calcitonin Gene-Related PeptideMESH
Cells, CulturedMESH
Cyclic AMP/metabolismMESH
Glomerular Filtration Rate/drug effectsMESH
Glomerular Mesangium/metabolismMESH
Kidney/physiologyMESH
KineticsMESH
MaleMESH
Neuropeptides/pharmacologyMESH
RatsMESH
Rats, Inbred StrainsMESH
Renal Circulation/drug effectsMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:26979
Owner only: item control page

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