Renal mesangium is a target for calcitonin gene-related peptide

URN to cite this document:: urn:nbn:de:bvb:355-epub-269799
DOI to cite this document:: 10.5283/epub.26979

Kurtz, Armin ; Schurek, H. J. ; Jelkmann, W. ; Muff, R. ; Lipp, H. P. ; Heckmann, U. ; Eckardt, Kai-Uwe ; Scholz, Holger ; Fischer, J. A. ; Bauer, Christian

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Date of publication of this fulltext: 06 Dec 2012 13:38

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Abstract

Rat calcitonin gene-related peptide (CGRP alpha; EC50, 1 nM) was shown to stimulate cAMP formation in cultured rat renal mesangial cells. CGRP concentration dependently (EC50, 1 nM) also inhibited contraction of mesangial cells by angiotensin II (10 nM). Angiotensin II (10 nM) caused a transient increase of the intracellular calcium concentration from 140 nM to 480 nM in the mesangial cells, but ...