Regulation of erythropoietin production is related to proximal tubular function

URN to cite this document:: urn:nbn:de:bvb:355-epub-269804
DOI to cite this document:: 10.5283/epub.26980

Eckardt, K. U. ; Kurtz, Armin ; Bauer, C.

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Date of publication of this fulltext: 05 Dec 2012 10:36

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Abstract

Regulation of renal erythropoietin (EPO) production is based on an intrarenal oxygen sensor. Whereas the sensitivity of this oxygen sensor to variations in renal oxygen supply is well established, the influence of changes in renal oxygen consumption has not yet been elucidated. Diuretic drugs, which inhibit active sodium reabsorption, reduce tubular oxygen consumption. We therefore investigated ...