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Stimulation of renin secretion by potassium-channel activation with cromakalim

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Ferrier, C. P. ; Kurtz, Armin ; Lehner, P. ; Shaw, S. G. ; Pusterla, C. ; Saxenhofer, H. ; Weidmann, P.
Date of publication of this fulltext: 20 Dec 2012 14:30


The cardiovascular and endocrine profile of cromakalim has been studied in 8 healthy men (age 25 +/- 2 years: means SEM) and its influence on renin release from cultured rat juxtaglomerular cells in vitro has also been examined. According to a double-blind, randomized sequence the subjects received placebo or cromakalim 1 mg as a single daily oral dose for 5 days. Compared to placebo, cromakalim ...


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