Regulation der Erythropoietin-Bildung [Regulation of erythropoietin synthesis]

URN to cite this document:: urn:nbn:de:bvb:355-epub-269885
DOI to cite this document:: 10.5283/epub.26988

Bauer, Christian ; Kurtz, Armin ; Eckardt, Kai-Uwe ; Tannahill, L.

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Date of publication of this fulltext: 14 Dec 2012 09:54

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Abstract

The main regulatory hormone for the control of erythropoiesis is erythropoietin (EPO). This glycoprotein has a molecular weight of 34,000 daltons, about 40% of which is represented by carbohydrates. EPO leads to an enhanced mitosis and differentiation of erythroid precursors (colony-forming unit erythroid) in the bone marrow by binding to specific receptors. The major stimulus for EPO formation ...