Erythropoiese und Serumerythropoietinkonzentration vor und nach Nierenallotransplantation [Erythropoiesis and serum erythropoietin concentrations before and after kidney allotransplantation]

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urn:nbn:de:bvb:355-epub-269906 Copy

Keusch, G. ; Kurtz, Armin ; Fehr, J. ; Eckardt, Kai-Uwe ; Frei, D. ; Bauer, Christian ; Binswanger, U.

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Date of publication of this fulltext: 14 Dec 2012 09:49

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Details

Item type:	Article
Journal or Publication Title:	Nephron
Publisher:	Karger
Volume:	51 Suppl 1
Page Range:	pp. 29-33
Date:	1989
Institutions:	Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:	Value Type 2644579 PubMed ID
Classification:	Notation Type Erythropoiesis MESH Erythropoietin/blood MESH Hematocrit MESH Humans MESH Kidney Transplantation MESH Radioimmunoassay MESH Renal Dialysis MESH Reticulocytes/analysis MESH Time Factors MESH
Dewey Decimal Classification:	500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	26990

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Abstract

Hematological parameters and serum erythropoietin (EPO) levels were measured before and sequentially after grafting in 50 consecutive cadaver renal transplant recipients. EPO was estimated using a sensitive radioimmunoassay. Values for nonanemic controls were 15-25 mU/ml. Mean hematological values before transplantation were as follows: hemoglobin 9.7 +/- 2.4 g/dl; hematocrit 29 +/- 8%; corrected ...

Abstract

Hematological parameters and serum erythropoietin (EPO) levels were measured before and sequentially after grafting in 50 consecutive cadaver renal transplant recipients. EPO was estimated using a sensitive radioimmunoassay. Values for nonanemic controls were 15-25 mU/ml. Mean hematological values before transplantation were as follows: hemoglobin 9.7 +/- 2.4 g/dl; hematocrit 29 +/- 8%; corrected reticulocytes count 15 +/- 8% and EPO 29 +/- 23 (11-131) mU/ml. In the entire studied population, 35 patients had inadequate low EPO levels for their degree of anemia. In the whole population, there was a significant positive exponential correlation between EPO and hematocrit (r = 0.31; p less than 0.05). In the subset of patients with underlying cystic kidney disease and in hemodialysis patients treated with recombinant human EPO, hemoglobin, hematocrit and EPO levels were higher when compared to hemodialysis or CAPD patients with other kidney diseases. Following successful renal transplantation, EPO increased to 45 +/- 31 mU/ml at 1 month and then decreased to 25 +/- 18, 18 +/- 7 and 19 +/- 4 mU/ml at 3,6 and 9 months, respectively. Within the 1st month after transplantation there was a 4-fold increase in reticulocytes from 9 +/- 5 to 38 +/- 14%, followed by a slow decrease over the next several months to 23 +/- 11% at 9 months. In contrast, the hematocrit level rose more gradually from 28 +/- 7 to 44 +/- 6% at 9 months. In 25 of 36 patients with a functioning graft who were followed for more than 6 months, anemia was corrected and 11 patients remained slightly anemic with a mean hematocrit level of 36 +/- 4%.

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