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Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats

URN to cite this document:
urn:nbn:de:bvb:355-epub-269933
Kurtz, Armin ; Zapf, J. ; Eckardt, Kai-Uwe ; Clemons, G. ; Froesch, E. R. ; Bauer, C.
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Date of publication of this fulltext: 08 Jan 2013 08:32


Abstract

Stimulation of erythropoiesis during growth is necessary to ensure proportionality between erythrocyte mass and body mass. However, the way by which erythrocyte formation is adapted to body growth is still unknown. Growth arrest in hypophysectomized rats is accompanied by decreased erythropoiesis. We have, therefore, examined whether insulin-like growth factor I (IGF-I), the mediator of growth ...

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