Calcitonin gene-related peptide is a stimulator of renin secretion

URN to cite this document:: urn:nbn:de:bvb:355-epub-269948
DOI to cite this document:: 10.5283/epub.26994

Kurtz, Armin ; Muff, R. ; Born, W. ; Lundberg, J. M. ; Millberg, B. I. ; Gnädinger, M. P. ; Uehlinger, D. E. ; Weidmann, P. ; Hökfelt, T. ; Fischer, J. A.

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Date of publication of this fulltext: 08 Jan 2013 08:31

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Abstract

Calcitonin gene-related peptide (CGRP) was found to stimulate renin secretion in vivo in normal human volunteers. Moreover, CGRP stimulated the release of renin in vitro from isolated rat renal juxtaglomerular cells (half-maximal effective concentration [EC50] 100 nM) concomitant with stimulation of cAMP production (EC50 60 nM). Immunoreactive CGRP was recognized in rat renal cortical nerve ...