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Calcitonin gene-related peptide is a stimulator of renin secretion

Kurtz, Armin, Muff, R., Born, W., Lundberg, .J M., Millberg, B. I., Gnädinger, M. P., Uehlinger, D. E., Weidmann, P., Hökfelt, T. and Fischer, J .A. (1988) Calcitonin gene-related peptide is a stimulator of renin secretion. The Journal of clinical investigation 82 (2), pp. 538-543.

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Abstract

Calcitonin gene-related peptide (CGRP) was found to stimulate renin secretion in vivo in normal human volunteers. Moreover, CGRP stimulated the release of renin in vitro from isolated rat renal juxtaglomerular cells (half-maximal effective concentration [EC50] 100 nM) concomitant with stimulation of cAMP production (EC50 60 nM). Immunoreactive CGRP was recognized in rat renal cortical nerve ...

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Item type:Article
Date:1988
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
2841355PubMed ID
10.1172/JCI113629DOI
Classification:
NotationType
AnimalsMESH
Calcitonin/geneticsMESH
Calcitonin Gene-Related PeptideMESH
Cyclic AMP/metabolismMESH
Fluorescent Antibody TechniqueMESH
HumansMESH
Infusions, IntravenousMESH
Juxtaglomerular Apparatus/cytologyMESH
Kidney Cortex/metabolismMESH
MaleMESH
Nerve Fibers/analysisMESH
Neuropeptides/pharmacologyMESH
RatsMESH
Renin/secretionMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:26994
Owner only: item control page

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