Cyclosporine A enhances renin secretion and production in isolated juxtaglomerular cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-269956

Kurtz, Armin ; Della Bruna, R. ; Kühn, K.

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Date of publication of this fulltext: 06 Dec 2012 13:32

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Abstract

Stimulation of the renin-angiotensin system is a major side effect of the fungoid immunosuppressant cyclosporine A (CyA). The aim of this study was to find out whether or not this effect of CyA results from a direct interaction with renal juxtaglomerular (JG) cells, which are the site of renal renin synthesis and release. Using primary cell cultures from rat renal cortex containing more than 80% ...