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Role of cGMP as second messenger of adenosine in the inhibition of renin release

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Kurtz, Armin ; Della Bruna, R. ; Pfeilschifter, J. ; Bauer, Christian
Date of publication of this fulltext: 08 Jan 2013 08:29


Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release. Using short term cultures of juxtaglomerular cells isolated from rat kidneys, we found that adenosine inhibited spontaneous renin release from these cells up to ...


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