Kurtz, Armin, Pfeilschifter, J., Kühn, K. and Koch, K. M.
(1987)
Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells.
Biochemical and biophysical research communications 147 (2), pp. 542-549.
Date of publication of this fulltext: 08 Jan 2013 08:24at PubMed
Abstract
The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study. We found that CyA time and concentration dependently (ED50:500 ng/ml) inhibited PGE2 release from the cells. CyA attenuated both basal and PGE2 release evoked by angiotensin II (10(-10)-10(-6) M), arginine vasopressin (10(-10)-10(-6) M) and ...
Abstract
The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study. We found that CyA time and concentration dependently (ED50:500 ng/ml) inhibited PGE2 release from the cells. CyA attenuated both basal and PGE2 release evoked by angiotensin II (10(-10)-10(-6) M), arginine vasopressin (10(-10)-10(-6) M) and ionomycin (10(-9)-10(-6) M). CyA (1 microgram/ml) did not affect the conversion of exogenous arachidonic acid (1 microM) into PGE2. The inhibitory effect of CyA was neutralized by high concentrations of the calcium ionophore ionomycin (greater than 3 X 10(-6) M). Taken together our results indicate that CyA inhibits both basal and vasoconstrictor evoked PGE2 release from vascular smooth muscle by impairing the availability of free arachidonic acid rather than by inhibiting the conversion of arachidonic acid into PGE2.
Export bibliographical data
| Item type: | Article |
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| Date: | 1987 |
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| Institutions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
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| Identification Number: | | Value | Type |
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| 3115263 | PubMed ID |
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| Classification: | | Notation | Type |
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| Angiotensin II/pharmacology | MESH | | Animals | MESH | | Aorta | MESH | | Arachidonic Acid | MESH | | Arachidonic Acids/metabolism | MESH | | Arginine Vasopressin/pharmacology | MESH | | Cells, Cultured | MESH | | Cyclosporins/pharmacology | MESH | | Dinoprostone | MESH | | Ethers/pharmacology | MESH | | Ionomycin | MESH | | Muscle, Smooth, Vascular/metabolism | MESH | | Phospholipases/metabolism | MESH | | Prostaglandin-Endoperoxide Synthases/metabolism | MESH | | Prostaglandins E/metabolism | MESH | | Rats | MESH |
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| Dewey Decimal Classification: | 500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine |
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| Status: | Published |
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| Refereed: | Yes, this version has been refereed |
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| Created at the University of Regensburg: | Unknown |
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| Item ID: | 26999 |
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