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Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells

Kurtz, Armin, Pfeilschifter, J., Kühn, K. and Koch, K. M. (1987) Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells. Biochemical and biophysical research communications 147 (2), pp. 542-549.

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Abstract

The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study. We found that CyA time and concentration dependently (ED50:500 ng/ml) inhibited PGE2 release from the cells. CyA attenuated both basal and PGE2 release evoked by angiotensin II (10(-10)-10(-6) M), arginine vasopressin (10(-10)-10(-6) M) and ...

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Item type:Article
Date:1987
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
3115263PubMed ID
Classification:
NotationType
Angiotensin II/pharmacologyMESH
AnimalsMESH
AortaMESH
Arachidonic AcidMESH
Arachidonic Acids/metabolismMESH
Arginine Vasopressin/pharmacologyMESH
Cells, CulturedMESH
Cyclosporins/pharmacologyMESH
DinoprostoneMESH
Ethers/pharmacologyMESH
IonomycinMESH
Muscle, Smooth, Vascular/metabolismMESH
Phospholipases/metabolismMESH
Prostaglandin-Endoperoxide Synthases/metabolismMESH
Prostaglandins E/metabolismMESH
RatsMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:26999
Owner only: item control page

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