Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-269995

Kurtz, Armin ; Pfeilschifter, J. ; Kühn, K. ; Koch, K. M.

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Date of publication of this fulltext: 08 Jan 2013 08:24

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Abstract

The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study. We found that CyA time and concentration dependently (ED50:500 ng/ml) inhibited PGE2 release from the cells. CyA attenuated both basal and PGE2 release evoked by angiotensin II (10(-10)-10(-6) M), arginine vasopressin (10(-10)-10(-6) M) and ...