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Atrial natriuretic peptide inhibits renin release from juxtaglomerular cells by a cGMP-mediated process

Kurtz, Armin, Della Bruna, R., Pfeilschifter, J., Taugner, R. and Bauer, Christian (1986) Atrial natriuretic peptide inhibits renin release from juxtaglomerular cells by a cGMP-mediated process. Proceedings of the National Academy of Sciences of the United States of America : PNAS 83 (13), pp. 4769-4773.

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Date of publication of this fulltext: 08 Jan 2013 08:27

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Abstract

We have examined the effect of a synthetic analogue of human alpha-atrial natriuretic peptide (ANP), APII, on renin release in cultured renal juxtaglomerular cells (JGA cells). Using cell cultures containing 80-90% renal juxtaglomerular cells, we found that ANP (10(-13)-10(-9) M) strongly inhibited renin release from the cells in a dose-dependent fashion (ki, 10 pM) to about 10% of control. ...

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Item type:Article
Date:1986
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
3014509PubMed ID
Classification:
NotationType
Aminoquinolines/diagnostic useMESH
AnimalsMESH
Atrial Natriuretic Factor/pharmacologyMESH
Calcium/physiologyMESH
Cells, CulturedMESH
Cyclic GMP/physiologyMESH
Dose-Response Relationship, DrugMESH
Juxtaglomerular Apparatus/secretionMESH
RatsMESH
Renin/secretionMESH
Secretory Rate/drug effectsMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:27005
Owner only: item control page

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