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Atrial natriuretic peptide inhibits renin release from juxtaglomerular cells by a cGMP-mediated process

URN to cite this document:
Kurtz, Armin ; Della Bruna, R. ; Pfeilschifter, J. ; Taugner, R. ; Bauer, Christian
Date of publication of this fulltext: 08 Jan 2013 08:27


We have examined the effect of a synthetic analogue of human alpha-atrial natriuretic peptide (ANP), APII, on renin release in cultured renal juxtaglomerular cells (JGA cells). Using cell cultures containing 80-90% renal juxtaglomerular cells, we found that ANP (10(-13)-10(-9) M) strongly inhibited renin release from the cells in a dose-dependent fashion (ki, 10 pM) to about 10% of control. ...


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