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Effect of synthetic atrial natriuretic peptide on rat renal juxtaglomerular cells

Kurtz, Armin ; Della Bruna, R. ; Pfeilschifter, J. ; Bauer, Christian


We examined the effect of synthetic atrial natriuretic peptide (ANP) on unstimulated renin release from rat renal juxtaglomerular cells. Using renal cortical cell cultures containing 80-90% juxtaglomerular cells, we found that ANP strongly inhibited renin release from the cells in a dose-dependent fashion. Half-maximal inhibition was observed at 10(-11) mol/l ANP. Furthermore, ANP produced a rise ...


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