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Effect of synthetic atrial natriuretic peptide on rat renal juxtaglomerular cells

Kurtz, Armin, Della Bruna, R., Pfeilschifter, J. and Bauer, Christian (1986) Effect of synthetic atrial natriuretic peptide on rat renal juxtaglomerular cells. Journal of hypertension. Supplement 4 (2), S57-S60.

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Abstract

We examined the effect of synthetic atrial natriuretic peptide (ANP) on unstimulated renin release from rat renal juxtaglomerular cells. Using renal cortical cell cultures containing 80-90% juxtaglomerular cells, we found that ANP strongly inhibited renin release from the cells in a dose-dependent fashion. Half-maximal inhibition was observed at 10(-11) mol/l ANP. Furthermore, ANP produced a rise ...

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Item type:Article
Date:1986
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
3014096PubMed ID
Classification:
NotationType
AnimalsMESH
Atrial Natriuretic Factor/pharmacologyMESH
Calcium/metabolismMESH
Cyclic AMP/metabolismMESH
Cyclic GMP/metabolismMESH
Diuretics/pharmacologyMESH
Juxtaglomerular Apparatus/metabolismMESH
Peptide Fragments/pharmacologyMESH
RatsMESH
Renin/secretionMESH
Verapamil/pharmacologyMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:27006
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