Role of phospholipase C and protein kinase C in vasoconstrictor-induced prostaglandin synthesis in cultured rat renal mesangial cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-270097
DOI to cite this document:: 10.5283/epub.27009

Pfeilschifter, J. ; Kurtz, Armin ; Bauer, Christian

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Date of publication of this fulltext: 08 Jan 2013 08:11

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Abstract

It was the aim of the present study to find out if a common mechanism exists by which the vasoconstrictive hormones angiotension II, noradrenaline and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC) increase prostaglandin E2 (PGE2) synthesis in cultures of rat renal mesangial cells. Angiotension II, noradrenaline and AGEPC stimulated PGE2 synthesis and uptake of 45Ca2+ in cultured ...