Activity in fetal bovine serum that stimulates erythroid colony formation in fetal mouse livers is insulinlike growth factor I

URN to cite this document:: urn:nbn:de:bvb:355-epub-270136
DOI to cite this document:: 10.5283/epub.27013

Kurtz, Armin ; Härtl, W. ; Jelkmann, W. ; Zapf, J. ; Bauer, Christian

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Date of publication of this fulltext: 08 Jan 2013 08:17

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Abstract

In the present study, the erythropoietic activity of fetal serum was characterized. Using fetal bovine serum (FBS) as a source of the erythropoietic activity and serum-free cultures of fetal mouse livers (FMLC assay) as a detection system, we found that FBS stimulated colony formation from late erythroid progenitor cells (CFU-E) in a dose-dependent fashion. The slope of the dose-response curve, ...