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Activity in fetal bovine serum that stimulates erythroid colony formation in fetal mouse livers is insulinlike growth factor I

Kurtz, Armin, Härtl, W., Jelkmann, W., Zapf, J. and Bauer, Christian (1985) Activity in fetal bovine serum that stimulates erythroid colony formation in fetal mouse livers is insulinlike growth factor I. The Journal of clinical investigation 76 (4), pp. 1643-1648.

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Abstract

In the present study, the erythropoietic activity of fetal serum was characterized. Using fetal bovine serum (FBS) as a source of the erythropoietic activity and serum-free cultures of fetal mouse livers (FMLC assay) as a detection system, we found that FBS stimulated colony formation from late erythroid progenitor cells (CFU-E) in a dose-dependent fashion. The slope of the dose-response curve, ...

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Item type:Article
Date:1985
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
4056043PubMed ID
10.1172/JCI112149DOI
Classification:
NotationType
AnimalsMESH
Antibodies/immunologyMESH
Cattle/bloodMESH
Chromatography, GelMESH
Colony-Forming Units AssayMESH
Dose-Response Relationship, DrugMESH
Erythropoiesis/drug effectsMESH
Fetal Blood/analysisMESH
Hematopoietic Stem Cells/drug effectsMESH
Insulin-Like Growth Factor I/pharmacologyMESH
Liver/embryologyMESH
MiceMESH
Organ Culture TechniquesMESH
Somatomedins/pharmacologyMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:27013
Owner only: item control page

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