Hypoxia enhances prostaglandin synthesis in renal mesangial cell cultures

URN to cite this document:: urn:nbn:de:bvb:355-epub-270154
DOI to cite this document:: 10.5283/epub.27015

Jelkmann, W. ; Kurtz, Armin ; Förstermann, U. ; Pfeilschifter, J. ; Bauer, Christian

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Date of publication of this fulltext: 08 Jan 2013 14:23

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Abstract

In view of recent findings which suggest that renal prostaglandins mediate the effect of hypoxia on erythropoietin production, we have studied whether hypoxia is a stimulus for in vitro prostaglandin synthesis. Studies were carried out in rat renal mesangial cell cultures which produce erythropoietin in an oxygen-dependent manner. Production rates of PGE2 and in specified samples also of ...