Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-270165
DOI to cite this document:: 10.5283/epub.27016

Pfeilschifter, J. ; Kurtz, Armin ; Bauer, Christian

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Date of publication of this fulltext: 08 Jan 2013 14:22

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Abstract

Acetylglyceryl ether phosphorylcholine (AGEPC), commonly known as platelet activating factor, was found to strongly inhibit renin secretion in cultures rich in juxtaglomerular cells. This inhibitory action of AGEPC was accompanied by an enhanced calcium permeability of the cell membrane as evaluated from measurements of the uptake of 45Ca. Simultaneous addition of the calcium channel blocker ...