Activation of phospholipase C and prostaglandin synthesis by [arginine]vasopressin in cultures

URN to cite this document:: urn:nbn:de:bvb:355-epub-270173
DOI to cite this document:: 10.5283/epub.27017

Pfeilschifter, J. ; Kurtz, Armin ; Bauer, Christian

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Date of publication of this fulltext: 08 Jan 2013 09:13

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Abstract

[Arginine]vasopressin (AVP) stimulates maximal prostaglandin E2 production in cultured rat renal mesangial cells within 2 min. As early as 10s after addition of AVP (10(-6)M) a significant loss of radioactivity from phosphatidylinositol 4,5-bisphosphate but not from phosphatidylinositol 4-phosphate and phosphatidylinositol was observed in cells prelabelled with 32Pi. Cells labelled with ...