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Renal mesangial cell cultures as a model for study of erythropoietin production

URN zum Zitieren dieses Dokuments:
urn:nbn:de:bvb:355-epub-270196
DOI zum Zitieren dieses Dokuments:
10.5283/epub.27019
Kurtz, Armin ; Jelkmann, W. ; Sinowatz, F. ; Bauer, Christian
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Veröffentlichungsdatum dieses Volltextes: 08 Jan 2013 14:12



Zusammenfassung

Mesangial cells derived from isolated glomeruli of rat kidney were grown as homogeneous cell lines in culture. They released, into the culture medium, erythropoietin that had free terminal galactosyl residues and was therefore not active in vivo. The production of erythropoietin by these cells was significantly enhanced by either lowering the PO2 in the incubation atmosphere or by adding cobalt ...

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