Renal mesangial cell cultures as a model for study of erythropoietin production

URN to cite this document:: urn:nbn:de:bvb:355-epub-270196
DOI to cite this document:: 10.5283/epub.27019

Kurtz, Armin ; Jelkmann, W. ; Sinowatz, F. ; Bauer, Christian

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Date of publication of this fulltext: 08 Jan 2013 14:12

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Abstract

Mesangial cells derived from isolated glomeruli of rat kidney were grown as homogeneous cell lines in culture. They released, into the culture medium, erythropoietin that had free terminal galactosyl residues and was therefore not active in vivo. The production of erythropoietin by these cells was significantly enhanced by either lowering the PO2 in the incubation atmosphere or by adding cobalt ...