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Reactivity Assessment of Chalcones by a Kinetic Thiol Assay

Amslinger, Sabine, Al-Rifai, Nafisah, Winter, Katrin, Wörmann, Kilian, Scholz, Rebekka, Baumeister, Paul and Wild, Martin (2013) Reactivity Assessment of Chalcones by a Kinetic Thiol Assay. Organic & Biomolecular Chemistry 11, pp. 549-554.

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Date of publication of this fulltext: 17 Dec 2012 06:32

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The electrophilic nature of chalcones (1,3-diphenylprop-2-en-1-ones) and many other α,β-unsaturated carbonyl compounds is crucial for their biological activity, which is often based on thiol-mediated regulation processes. To better predict their biological activity a simple screening assay for the assessment of the second-order rate constants (k2) in thia-Michael additions was developed. Hence, a ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik
Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
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Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:27133
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