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Reactivity Assessment of Chalcones by a Kinetic Thiol Assay

URN to cite this document:
urn:nbn:de:bvb:355-epub-271332
Amslinger, Sabine ; Al-Rifai, Nafisah ; Winter, Katrin ; Wörmann, Kilian ; Scholz, Rebekka ; Baumeister, Paul ; Wild, Martin
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Date of publication of this fulltext: 17 Dec 2012 06:32


Abstract

The electrophilic nature of chalcones (1,3-diphenylprop-2-en-1-ones) and many other α,β-unsaturated carbonyl compounds is crucial for their biological activity, which is often based on thiol-mediated regulation processes. To better predict their biological activity a simple screening assay for the assessment of the second-order rate constants (k2) in thia-Michael additions was developed. Hence, a ...

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