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Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney

URN to cite this document:
urn:nbn:de:bvb:355-epub-272038
Scholz, H. ; Kurtz, Armin
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Date of publication of this fulltext: 08 Jan 2013 14:42


Abstract

Using isolated rat kidneys perfused at controlled pressure, we examined a potential role of endothelium-derived relaxing factor (EDRF) in the pressure control of renin secretion. We found that stimulation of EDRF release by acetylcholine (1 mumol/liter) increased mean perfusate flow rates from 15.0 +/- 0.5 to 18.0 +/- 0.5 ml/min per g and average renin secretion rates from 3.5 +/- 0.5 to 16.0 +/- ...

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