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The impact of intragenic CpG content on epigenetic control of transgene expression in mammalian cells

Krinner, Simone (2014) The impact of intragenic CpG content on epigenetic control of transgene expression in mammalian cells. PhD, Universität Regensburg.

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Date of publication of this fulltext: 24 Jan 2014 12:30

Abstract (English)

The improvement of gene therapy applications and efficient production of recombinant therapeutics in mammalian cells is a growing field of interest in medical and pharmaceutical research. Plasmid-DNA (pDNA)-based vector systems offer an innovative gene transfer strategy due to their high stability, cost efficient production and their excellent safety profile. Despite these advantages, the ...

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Translation of the abstract (German)

Die effiziente Produktion rekombinanter Therapeutika in Säugerzellen und Verbesserung gentherapeutischer Verfahren sind bedeutende und expandierende Felder in der medizinischen und pharmazeutischen Forschung. Plasmid-DNA (pDNA)-basierte Vektorsysteme stellen aufgrund ihrer Stabilität, der kostengünstigen Produktion sowie ihres hervorragenden Sicherheitsprofils ein innovatives Gentransfer-System ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:24 January 2014
Referee:Prof. Dr. Ralf Wagner
Date of exam:22 January 2013
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Keywords:CpG, epigenetic control, transgene expression, epigenetische Kontrolle, Transgen-Expression, gene therapy, Gentherapie
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:27410
Owner only: item control page

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