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Kinetic Resolution of Racemic Aldehydes by Reaction With Chiral 2-Phosphono-propionates

Rein, Tobias ; Anvelt, Jaan ; Soone, Alo ; Kreuder, Reinhard ; Wulff, Christian ; Reiser, Oliver



Abstract

Kinetic resolutions of the racemic aldehydes 3a-c by reaction with chiral phosphonopropionates 2 have been studied. Reagent 2d gives (Z)-alkene products in good yields and diastereoselectivities from all three substrates.


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