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New GABA amides activating GABA A-receptors

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Raster, Peter ; Späth, Andreas ; Bultakova, Svetlana ; Gorostiza, Pau ; König, Burkhard ; Bregestovski, Piotr
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Date of publication of this fulltext: 06 Mar 2013 15:01


We have prepared a series of new and some literature-reported GABA-amides and determined their effect on the activation of GABAA-receptors expressed in CHO cells. Special attention was paid to the purification of the target compounds to remove even traces of GABA contaminations, which may arise from deprotection steps in the synthesis. GABA-amides were previously reported to be partial, full or ...


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