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New GABA amides activating GABA A-receptors

Raster, Peter, Späth, Andreas, Bultakova, Svetlana, Gorostiza, Pau, König, Burkhard and Bregestovski, Piotr (2013) New GABA amides activating GABA A-receptors. Beilstein Journal of Organic Chemistry 9, pp. 406-410.

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Date of publication of this fulltext: 06 Mar 2013 15:01

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Abstract

We have prepared a series of new and some literature-reported GABA-amides and determined their effect on the activation of GABAA-receptors expressed in CHO cells. Special attention was paid to the purification of the target compounds to remove even traces of GABA contaminations, which may arise from deprotection steps in the synthesis. GABA-amides were previously reported to be partial, full or ...

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Item type:Article
Date:2013
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Identification Number:
ValueType
10.3762/bjoc.9.42DOI
Keywords:CHO-cells; GABA; GABA-amides; GABA-superagonist; patch-clamp recording
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:27814
Owner only: item control page

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