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Hypertrophie chondrogen differenzierender mesenchymaler Stammzellen im dreidimensionalen System

URN to cite this document:
urn:nbn:de:bvb:355-epub-278266
Teegen, Eva Maria
Date of publication of this fulltext: 13 Mar 2013 15:57


Abstract (German)

Tissue Engineering bietet Therapieoptionen wie die autologe Chondrozytentrans-plantation, verknüpft mit dem Nachteil, dass bei der Zellentnahme gesundes Gewebe verletzt wird (Donormorbidität). Einfacher lassen sich humane mesenchymalen Stammzellen aus dem Beckenkamm gewinnen, in vitro proliferieren und zu reifen Chondrozyten differenzieren (11, 50, 80, 89, 93, 102, 112). In vitro aber ...

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Translation of the abstract (English)

Tissue engineering offers therapy concepts like the autologous chondrocyte transplantation going along with the drawback of injured healthy tissue (donormorbidity). Human mesenchymal stem cells (MSC) are easily extracted from the iliac crest, in vitro proliferated and differentiated to mature chondrocytes (11, 50, 80, 89, 93, 102, 112). But predifferentiated MSCs expressed hypertrophic markers in ...

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