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Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats

Schmid, Peter M., Resch, Markus, Schach, Christian, Birner, Christoph, Riegger, Günter A. J., Luchner, Andreas and Endemann, Dierk H. (2013) Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats. Cardiovascular Diabetology 12, p. 46.

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Date of publication of this fulltext: 05 Apr 2013 13:47

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Abstract

Background Adiponectin is able to induce NO-dependent vasodilation in Zucker lean (ZL) rats, but this effect is clearly alleviated in their diabetic littermates, the Zucker diabetic fatty (ZDF) rats. ZDF rats also exhibit hypoadiponectinemia and a suppressed expression of APPL1, an adaptor protein of the adiponectin receptors, in mesenteric resistance arteries. Whether an antidiabetic treatment ...

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Item type:Article
Date:2013
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/1475-2840-12-46DOI
Keywords:Adiponectin; APPL1; AdipoR; eNOS; Insulin; Metformin; Diabetes mellitus type 2
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28000
Owner only: item control page

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