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Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats

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Schmid, Peter M. ; Resch, Markus ; Schach, Christian ; Birner, Christoph ; Riegger, Günter A. J. ; Luchner, Andreas ; Endemann, Dierk H.
License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 05 Apr 2013 13:47


Background Adiponectin is able to induce NO-dependent vasodilation in Zucker lean (ZL) rats, but this effect is clearly alleviated in their diabetic littermates, the Zucker diabetic fatty (ZDF) rats. ZDF rats also exhibit hypoadiponectinemia and a suppressed expression of APPL1, an adaptor protein of the adiponectin receptors, in mesenteric resistance arteries. Whether an antidiabetic treatment ...


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