Go to content
UR Home

Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats

URN to cite this document:
urn:nbn:de:bvb:355-epub-280003
Schmid, Peter M. ; Resch, Markus ; Schach, Christian ; Birner, Christoph ; Riegger, Günter A. J. ; Luchner, Andreas ; Endemann, Dierk H.
[img]
Preview
License: Creative Commons Attribution 3.0
PDF - Published Version
(611kB)
Date of publication of this fulltext: 05 Apr 2013 13:47


Abstract

Background Adiponectin is able to induce NO-dependent vasodilation in Zucker lean (ZL) rats, but this effect is clearly alleviated in their diabetic littermates, the Zucker diabetic fatty (ZDF) rats. ZDF rats also exhibit hypoadiponectinemia and a suppressed expression of APPL1, an adaptor protein of the adiponectin receptors, in mesenteric resistance arteries. Whether an antidiabetic treatment ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons