Synthesis of substituted hydantoins in low melting mixtures

Abstract

A novel domino synthesis of 1,3,5-trisubstituted hydantoin derivatives has been developed in low melting l-(+)-tartaric acid-DMU melt mixtures. The functionalized hydantoins are obtained in good yields from β,γ-unsaturated ketoacids and urea under environmentally benign and simple reaction conditions.