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Synthesis of substituted hydantoins in low melting mixtures

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Gore, Sangram ; Chinthapally, Kiran ; Baskaran, Sundarababu ; König, Burkhard
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 16 May 2013 06:23


A novel domino synthesis of 1,3,5-trisubstituted hydantoin derivatives has been developed in low melting l-(+)-tartaric acid-DMU melt mixtures. The functionalized hydantoins are obtained in good yields from β,γ-unsaturated ketoacids and urea under environmentally benign and simple reaction conditions.

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