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Synthesis and pharmacological characterization of new tetrahydrofuran based compounds as conformationally constrained histamine receptor ligands

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Bodensteiner, Julian ; Baumeister, Paul ; Geyer, Roland ; Buschauer, Armin ; Reiser, Oliver
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 27 Aug 2013 07:24


A series of tetrahydrofuran based compounds with a bicyclic core that provides conformational restriction were synthesized and investigated by radioligand displacement studies and functional [(35)S]GTPγS binding assays at the human histamine receptor (hHR) subtypes. The amines and ((1S,3R,5S,6R)- and ((1S,3S,5S,6R)-3-(1H-imidazol-5-yl)-2-oxabicyclo[3.1.0]hexan-6-yl)methanamine), exhibited ...


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