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GPER-1 acts as a tumor suppressor in ovarian cancer

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Ignatov, Tanja ; Modl, Saskia ; Thulig, Maike ; Weißenborn, Christine ; Treeck, Oliver ; Ortmann, Olaf ; Zenclussen, Ac ; Costa, Serban-Dan ; Kalinski, Thomas ; Ignatov, Atanas
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 03 Sep 2013 12:55


Background: It is known that the new membrane-bound estrogen receptor GPER-1 acts suppressive in breast cancer cells and its expression decreases during disease progression. This study was conducted to evaluate the GPER-1 expression in ovarian cancer and its correlation with progression. Its function was tested in vitro in ovarian cancer cells. PATIENTS AND METHODS: GPER-1 expression was ...


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