5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

URN to cite this document:: urn:nbn:de:bvb:355-epub-287892
DOI to cite this document:: 10.5283/epub.28789

Klug, Maja ; Schmidhofer, Sandra ; Gebhard, Claudia ; Andreesen, Reinhard ; Rehli, Michael

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Date of publication of this fulltext: 04 Sep 2013 05:51

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Abstract

Background: Cytosine methylation is a frequent epigenetic modification restricting the activity of gene regulatory elements. Whereas DNA methylation patterns are generally inherited during replication, both embryonic and somatic differentiation processes require the removal of cytosine methylation at specific gene loci to activate lineage-restricted elements. However, the exact mechanisms ...