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5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

Klug, Maja, Schmidhofer, Sandra, Gebhard, Claudia, Andreesen, Reinhard and Rehli, Michael (2013) 5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes. Genome biology 14 (5), R46.

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Date of publication of this fulltext: 04 Sep 2013 05:51

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Abstract

BACKGROUND: Cytosine methylation is a frequent epigenetic modification restricting the activity of gene regulatory elements. Whereas DNA methylation patterns are generally inherited during replication, both embryonic and somatic differentiation processes require the removal of cytosine methylation at specific gene loci to activate lineage-restricted elements. However, the exact mechanisms ...

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Item type:Article
Date:2013
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
23705593PubMed ID
10.1186/gb-2013-14-5-r46DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28789
Owner only: item control page

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