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Membrane trafficking of death receptors: implications on signalling

URN to cite this document:
urn:nbn:de:bvb:355-epub-288282
Schneider-Brachert, Wulf ; Heigl, Ulrike ; Ehrenschwender, Martin
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Date of publication of this fulltext: 11 Sep 2013 08:42


Abstract

Death receptors were initially recognised as potent inducers of apoptotic cell death and soon ambitious attempts were made to exploit selective ignition of controlled cellular suicide as therapeutic strategy in malignant diseases. However, the complexity of death receptor signalling has increased substantially during recent years. Beyond activation of the apoptotic cascade, involvement in a ...

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