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In vitro studies of the hepatotoxic and hepatoprotective potential and metabolism of chalcones and a tacrine-silibinin codrug

URN to cite this document:
urn:nbn:de:bvb:355-epub-288475
Zenger, Katharina
Date of publication of this fulltext: 17 Oct 2013 11:30


Abstract (English)

(1) Kava kava, traditionally used by the Pacific Islanders as a socio-ceremonial beverage and remedy, was approved as an anxiolytic drug in Western countries. However, the reports of severe hepatotoxic side effects led to the withdrawal of kava-containing products in most of these countries. Since then, responsible constituents and possible mechanisms of hepatotoxicity are controversially ...

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Translation of the abstract (German)

(1) Kava Kava, das traditionell auf vielen Pazifischen Inseln als zeremonieller Trunk und Heilmittel verwendet wird, war in westlichen Ländern als angstlösendes pflanzliches Arzneimittel zugelassen. Fallberichte über zum Teil schwerwiegende hepatotoxische Nebenwirkungen führten jedoch zur Marktrücknahme von Kava-haltigen Produkten in den meisten dieser Länder. Seitdem werden die für die Toxizität ...

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