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Sterile alpha motif containing 7 (Samd7) is a novel Crx-regulated transcriptional repressor in the retina

Hlawatsch, Julia (2013) Sterile alpha motif containing 7 (Samd7) is a novel Crx-regulated transcriptional repressor in the retina. PhD, Universität Regensburg.

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Date of publication of this fulltext: 20 Nov 2013 17:19

Abstract (English)

Inherited retinal diseases are mainly caused by mutations in genes that are highly expressed in photoreceptors of the retina. The majority of these genes is under the control of the transcription factor Cone rod homeobox (Crx), that acts as a master transcription factor in photoreceptors. Using a genome-wide chromatin immunoprecipitation dataset that highlights all potential in vivo targets of ...


Translation of the abstract (German)

Erbliche Netzhauterkrankungen werden hauptsächlich durch Mutationen in stark exprimierten Fotorezeptorgenen verursacht. Die meisten dieser Gene werden durch den Transkriptionsfaktor Cone rod homeobox (Crx) kontrolliert, einen sogenannten Master-Transkriptionsfaktor in Fotorezeptoren. Mittels einer genomweiten Chromatin-Immunpräzipitationsstudie, die alle potentiellen in vivo Zielgene von Crx ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:20 November 2013
Referee:Prof. Dr. Thomas Langmann
Date of exam:15 November 2013
Institutions:Medicine > Lehrstuhl für Humangenetik
Keywords:Samd7, Sterile alpha motif containing 7, SAM domain, Crx Chip-seq, transcriptional repressor
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29043
Owner only: item control page


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