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Function of the trigger loop in distinct steps of the transcription cycle

URN to cite this document:
urn:nbn:de:bvb:355-epub-291180
Fouqueau, Thomas
Date of publication of this fulltext: 05 Feb 2014 17:07


Abstract (English)

RNA polymerases (RNAPs) carry out transcription in all living organisms. Whereas only one RNAP is present in bacteria and archaea, eukaryotes possess three to five specialized nuclear RNA polymerases (RNAP I, II, III, IV and V). To date, various RNAP structures have elucidated functional mechanisms of transcription, but biochemical analysis on eukaryotic RNAP II mutants are generally restricted ...

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Translation of the abstract (German)

RNA Polymerasen (RNAPs) sind verantwortlich für die Transkription in allen Lebensformen. Während Bakterien und Archaeen nur eine RNAP besitzen, haben Eukaryonten drei bis fünf spezialisierte nukleare RNAPs (RNAP I, II, III, IV und V). In der Zwischenzeit haben verschiedene RNAP Strukturanalysen zum Verständnis des funktionellen Mechanismus der Transkription beigetragen, biochemische Studien von ...

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