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miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells

Kliese, N. ; Gobrecht, P. ; Pachow, D. ; Andrae, N. ; Wilisch-Neumann, A. ; Kirches, E. ; Riek-Burchardt, M. ; Angenstein, F. ; Reifenberger, G. ; Riemenschneider, Markus J. ; Meese, E. ; Panayotova-Dimitrova, D. ; Gutmann, D.H. ; Mawrin, C.



Abstract

Meningiomas are frequent, mostly benign intracranial or spinal tumors. A small subset of meningiomas is characterized by histological features of atypia or anaplasia that are associated with more aggressive biological behavior resulting in increased morbidity and mortality. Infiltration into the adjacent brain tissue is a major factor linked to higher recurrence rates. The molecular mechanisms of ...

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