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miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells

Kliese, N., Gobrecht, P., Pachow, D., Andrae, N., Wilisch-Neumann, A., Kirches, E., Riek-Burchardt, M., Angenstein, F., Reifenberger, G., Riemenschneider, Markus J., Meese, E., Panayotova-Dimitrova, D., Gutmann, D.H. and Mawrin, C. (2013) miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells. Oncogene 32 (39), pp. 4712-4720.

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Abstract

Meningiomas are frequent, mostly benign intracranial or spinal tumors. A small subset of meningiomas is characterized by histological features of atypia or anaplasia that are associated with more aggressive biological behavior resulting in increased morbidity and mortality. Infiltration into the adjacent brain tissue is a major factor linked to higher recurrence rates. The molecular mechanisms of ...

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Item type:Article
Date:2013
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
23108408PubMed ID
10.1038/onc.2012.468DOI
Classification:
NotationType
AnimalsMESH
Cell AdhesionMESH
Cell DifferentiationMESH
Cell DivisionMESH
Cell MovementMESH
Collagen Type V/geneticsMESH
Down-RegulationMESH
HumansMESH
Meningeal Neoplasms/pathologyMESH
Meningioma/pathologyMESH
MiceMESH
Mice, NudeMESH
MicroRNAs/physiologyMESH
Neoplasm GradingMESH
Neoplasm Invasiveness/physiopathologyMESH
Neoplasm Proteins/geneticsMESH
Neoplasm TransplantationMESH
RNA, Neoplasm/physiologyMESH
Tumor Stem Cell AssayMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29171
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