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SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation

Lindemann, Carina, Hackmann, Oliver, Delic, Sabit, Schmidt, Natalie, Reifenberger, Guido and Riemenschneider, Markus J. (2011) SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation. Acta neuropathologica 122 (2), pp. 241-251.

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Abstract

The suppressor of cytokine signaling 3 (SOCS3) gene is one of eight structurally related genes of the SOCS family and has been suggested to function as a tumor suppressor by inhibition of the JAK/STAT signaling pathway. We investigated 60 human gliomas of different histological types for SOCS3 alterations and found frequent SOCS3 promoter hypermethylation and transcriptional downregulation. ...

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Item type:Article
Date:2011
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
21590492PubMed ID
10.1007/s00401-011-0832-0DOI
Classification:
NotationType
Blotting, WesternMESH
Brain Neoplasms/pathologyMESH
DNA Methylation/geneticsMESH
DNA Mutational AnalysisMESH
Enzyme Activation/physiologyMESH
Focal Adhesion Kinase 1/metabolismMESH
Gene AmplificationMESH
Genes, erbB-1MESH
Glioma/pathologyMESH
HumansMESH
ImmunohistochemistryMESH
Neoplasm Invasiveness/geneticsMESH
Promoter Regions, Genetic/geneticsMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
STAT3 Transcription Factor/metabolismMESH
Signal Transduction/geneticsMESH
Suppressor of Cytokine Signaling Proteins/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29183
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