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Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner

Krampert, Monika, Chirasani, Sridhar Reddy, Wachs, Frank-Peter, Aigner, Robert, Bogdahn, Ulrich, Yingling, Jonathan M, Heldin, Carl-Henrik, Aigner, Ludwig and Heuchel, Rainer (2010) Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner. Molecular and cellular biology 30 (14), pp. 3685-3694.

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Abstract

Members of the transforming growth factor beta (TGF-beta) family of proteins modulate the proliferation, differentiation, and survival of many different cell types. Neural stem and progenitor cells (NPCs) in the adult brain are inhibited in their proliferation by TGF-beta and by bone morphogenetic proteins (BMPs). Here, we investigated neurogenesis in a hypomorphic mouse model for the TGF-beta ...

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Item type:Article
Date:2010
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
9584124PubMed ID
10.1128/MCB.00434-09DOI
Classification:
NotationType
Adult Stem Cells/metabolismMESH
AnimalsMESH
Bone Morphogenetic Proteins/metabolismMESH
Cell CycleMESH
Cell ProliferationMESH
ExonsMESH
MiceMESH
Mice, Mutant StrainsMESH
Mutagenesis, InsertionalMESH
Neurogenesis/physiologyMESH
Neurons/metabolismMESH
RNA, Messenger/metabolismMESH
Receptor, Epidermal Growth Factor/metabolismMESH
Signal TransductionMESH
Smad7 Protein/metabolismMESH
Transforming Growth Factor beta/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29206
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