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Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner

Krampert, Monika ; Chirasani, Sridhar Reddy ; Wachs, Frank-Peter ; Aigner, Robert ; Bogdahn, Ulrich ; Yingling, Jonathan M ; Heldin, Carl-Henrik ; Aigner, Ludwig ; Heuchel, Rainer



Abstract

Members of the transforming growth factor beta (TGF-beta) family of proteins modulate the proliferation, differentiation, and survival of many different cell types. Neural stem and progenitor cells (NPCs) in the adult brain are inhibited in their proliferation by TGF-beta and by bone morphogenetic proteins (BMPs). Here, we investigated neurogenesis in a hypomorphic mouse model for the TGF-beta ...

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