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MGMT promoter methylation in malignant gliomas

Riemenschneider, Markus J. ; Hegi, Monika E. ; Reifenberger, Guido



Abstract

The O(6)-methylguanine-DNA methyltransferase (MGMT) gene is located at chromosome 10q26 and codes for a DNA repair enzyme that--if active--can counteract the effects of alkylating chemotherapy. Malignant gliomas often have the MGMT gene inactivated due to aberrant methylation of its promoter region. The assessment of the MGMT promoter methylation status has become of clinical relevance as a ...

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