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Differential proteome analysis of human gliomas stratified for loss of heterozygosity on chromosomal arms 1p and 19q

Grzendowski, Michael ; Wolter, Marietta ; Riemenschneider, Markus J. ; Knobbe, Christiane B. ; Schlegel, Uwe ; Meyer, Helmut E. ; Reifenberger, Guido ; Stühler, Kai



Abstract

Combined deletion of chromosomal arms 1p and 19q is an independent prognostic marker in patients with oligodendroglial brain tumors, including oligodendrogliomas and oligoastrocytomas. However, the relevant genes in these chromosome arms and the molecular mechanisms underlying the prognostic significance of 1p/19q deletion are yet unknown. We used two-dimensional difference gel electrophoresis ...

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