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A biologically adapted dose-escalation approach, demonstrated for 18F-FET-PET in brain tumors

Rickhey, Mark ; Koelbl, Oliver ; Eilles, Christoph ; Bogner, Ludwig



Abstract

Purpose: To demonstrate the feasibility of a biologically adapted dose-escatation approach to brain tumors. Material and Methods: Due to the specific accumulation of fluoroethyltyrosine (FET) in brain tumors, F-18-FET-PET imaging is used to derive a voxel-by-voxel dose distribution. Although the kinetics of F-18-FET are not completely understood, the authors regard regions with high tracer uptake ...

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