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Glioblastoma with adipocyte-like tumor cell differentiation--histological and molecular features of a rare differentiation pattern

Rickert, Christian H. ; Riemenschneider, Markus J. ; Schachenmayr, Walter ; Richter, Hans-Peter ; Bockhorn, Jürgen ; Reifenberger, Guido ; Paulus, Werner


We report on three adult patients with primary glioblastomas showing prominent adipocytic (lipomatous) differentiation, hence referred to as "glioblastomas with adipocyte-like tumor cell differentiation." Histologically, the tumors demonstrated typical features of glioblastoma but additionally contained areas consisting of glial fibrillary acidic protein (GFAP)-positive astrocytic tumor cells ...


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