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Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss

Riemenschneider, Markus J., Reifenberger, Julia and Reifenberger, Guido (2008) Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss. International journal of cancer. Journal international du cancer 122 (11), pp. 2503-2510.

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Abstract

Deletion of the short arm of chromosome 1 is common in oligodendroglial tumors and has been identified as a powerful molecular marker for response to radio- and chemotherapy as well as favorable prognosis. Here, we investigated a series of 59 human primary gliomas for aberrations of the DIRAS3 (ARHI) gene, a maternally imprinted RAS-related tumor suppressor at 1p31. We found that DIRAS3 mRNA ...

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Item type:Article
Date:2008
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
18302158PubMed ID
10.1002/ijc.23409DOI
Classification:
NotationType
AllelesMESH
Astrocytoma/geneticsMESH
Brain Neoplasms/geneticsMESH
Chromosomes, Human, Pair 1MESH
CpG Islands/geneticsMESH
DNA MethylationMESH
DNA Mutational AnalysisMESH
Gene SilencingMESH
Glioma/pathologyMESH
HumansMESH
Loss of HeterozygosityMESH
Microsatellite RepeatsMESH
MutationMESH
Oligodendroglioma/geneticsMESH
Predictive Value of TestsMESH
PrognosisMESH
RNA, Messenger/metabolismMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Transcription, GeneticMESH
Tumor Markers, Biological/geneticsMESH
rho GTP-Binding Proteins/geneticsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29243
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